Current Opinion in Cell Biology ( IF 6.0 ) Pub Date : 2021-06-26 , DOI: 10.1016/j.ceb.2021.05.002 Rita Mateus 1 , Jana F Fuhrmann 2 , Natalie A Dye 3
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Organ and tissue growth result from an integration of biophysical communication across biological scales, both in time and space. In this review, we highlight new insight into the dynamic connections between control mechanisms operating at different length scales. First, we consider how the dynamics of chemical and electrical signaling in the shape of gradients or waves affect spatiotemporal signal interpretation. Then, we discuss the mechanics underlying dynamic cell behavior during oriented tissue growth, followed by the connections between signaling at the tissue and organismal levels.
中文翻译：
跨尺度增长：动态信号影响组织大小和形状
器官和组织的生长是跨生物尺度的生物物理通信在时间和空间上的整合的结果。在这篇综述中，我们强调了对在不同长度尺度上运行的控制机制之间的动态联系的新见解。首先，我们考虑梯度或波形式的化学和电信号的动力学如何影响时空信号解释。然后，我们讨论了定向组织生长过程中动态细胞行为的机制，然后讨论了组织和有机体水平信号之间的联系。
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