Regeneration and recovery of nerve tissues are a great challenge for medicine, and positively affect the quality of life of patients. The development of tissue engineering offers a new approach to the problem with the creation of multifunctional artificial scaffolds that act on various levels in the damaged tissue, providing physical and biochemical support for the growth of nerve cells. In this study, the effects of the use of a tubular scaffold made of polybutylene succinate (PBS), surgically positioned at the level of a sciatic nerve injured in rat, between the proximal stump and the distal one, was investigated. Scaffolds characterization was carried out by scanning electron microscopy and X-ray microcomputed tomography and magnetic resonance imaging, in vivo. The demonstration of the nerve regeneration was based on the evaluation of electroneurography, measuring the weight of gastrocnemius and tibialis anterior muscles, histological examination of regenerated nerves and observing the recovery of the locomotor activity of animals. The PBS tubular scaffold minimized iatrogenic trauma on the nerve, acting as a directional guide for the regenerating fibers by conveying them toward the distal stump. In this context, neurotrophic and neurotropic factors may accumulate and perform their functions, while invasion by macrophages and scar tissue is hampered.

中文翻译：

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用于周围神经再生的聚丁二酸丁二醇酯人工支架

神经组织的再生和恢复是医学的一大挑战，对患者的生活质量产生积极影响。组织工程的发展为创建多功能人工支架提供了一种新方法，该支架作用于受损组织的各个层面，为神经细胞的生长提供物理和生化支持。在这项研究中，研究了使用聚丁二酸丁二醇酯 (PBS) 制成的管状支架的效果，该支架通过手术定位在大鼠坐骨神经损伤的水平，位于近端残端和远端残端之间。支架表征通过扫描电子显微镜和 X 射线微计算机断层扫描和磁共振成像在体内进行。神经再生的示范是基于神经电图的评估，测量腓肠肌和胫骨前肌的重量，再生神经的组织学检查和观察动物运动活动的恢复。PBS 管状支架最大限度地减少了对神经的医源性创伤，通过将再生纤维输送到远端残端来充当再生纤维的定向引导。在这种情况下，神经营养和神经营养因子可能会积累并发挥其功能，而巨噬细胞和瘢痕组织的侵袭则受到阻碍。通过将再生纤维输送到远端残端，充当再生纤维的定向引导器。在这种情况下，神经营养和神经营养因子可能会积累并发挥其功能，而巨噬细胞和瘢痕组织的侵袭则受到阻碍。通过将再生纤维输送到远端残端，充当再生纤维的定向引导器。在这种情况下，神经营养和神经营养因子可能会积累并发挥其功能，而巨噬细胞和瘢痕组织的侵袭则受到阻碍。