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The cause of myopia development and progression: Theory, evidence, and treatment
Survey of Ophthalmology ( IF 5.1 ) Pub Date : 2021-06-25 , DOI: 10.1016/j.survophthal.2021.06.005
Antonio Medina 1
Affiliation  

I review the key findings and our current knowledge of the cause of myopia, making the connections among the reliable observations on myopia development and theory to arrive at a summary of what we know about myopia, the proposed prevailing theory, and applicable action.

Myopia is reaching epidemic proportions. It is estimated that half of the world's population will be myopic by 2050 unless new strategies to fight myopia are developed. Our high-level mathematical description of myopia is translated into clinical applications involving effective treatment and prevention.

A regulating mechanism controlling the refraction of the eye is intimately related to myopia. The approach at hand is to review our knowledge about emmetropization, connecting myopia and emmetropization feedback theory to unveil the cause of myopia.

Many observations discussed here test the validity of feedback theory positively. The cause of human myopia fits perfectly with the idea that emmetropization, in particular its feedback theory implementation, is the controlling mechanism behind myopia. They include near work, atropine, lenses, defocus, and outdoor versus indoor activities. The key findings in myopia research point the same way: myopia is the result of corrective lenses interfering with emmetropization.

We have enough knowledge to answer the question of whether myopia can be reversed or prevented. There is no need to have mathematical skills to apply theory to real cases. It is enough to know the predictions of the feedback theory of emmetropization.



中文翻译:

近视发展和发展的原因:理论、证据和治疗

我回顾了主要发现和我们目前对近视原因的了解,将关于近视发展的可靠观察与理论联系起来,以总结我们对近视的了解、提出的普遍理论和适用的行动。

近视正在达到流行病的程度。据估计,除非制定新的抗近视战略,否则到 2050 年,世界上一半的人口将患有近视。我们对近视的高级数学描述被转化为涉及有效治疗和预防的临床应用。

控制眼睛屈光度的调节机制与近视密切相关。手头的方法是回顾我们关于正视化的知识,将近视和正视化反馈理论联系起来,以揭示近视的原因。

这里讨论的许多观察结果都积极地检验了反馈理论的有效性。人类近视的成因完全符合正视化,特别是其反馈理论的实施,是近视背后的控制机制的观点。它们包括近距离工作、阿托品、镜片、散焦以及户外与室内活动。近视研究的主要发现指向相同的方向:近视是矫正镜片干扰正视的结果。

我们有足够的知识来回答近视是否可以逆转或预防的问题。无需具备数学技能即可将理论应用于实际案例。了解正视化反馈理论的预测就足够了。

更新日期:2021-06-25
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