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Association of fine particulate matter air pollution and its constituents with lung function: The China Pulmonary Health study
Environment International ( IF 10.3 ) Pub Date : 2021-06-26 , DOI: 10.1016/j.envint.2021.106707
Ting Yang 1 , Renjie Chen 2 , Xiaoying Gu 3 , Jianying Xu 4 , Lan Yang 5 , Jianping Zhao 6 , Xiangyan Zhang 7 , Chunxue Bai 8 , Jian Kang 9 , Pixin Ran 10 , Huahao Shen 11 , Fuqiang Wen 12 , Kewu Huang 13 , Yahong Chen 14 , Tieying Sun 15 , Guangliang Shan 16 , Yingxiang Lin 13 , Sinan Wu 3 , Jianguo Zhu 17 , Ruiying Wang 4 , Zhihong Shi 5 , Yongjian Xu 6 , Xianwei Ye 7 , Yuanlin Song 8 , Qiuyue Wang 9 , Yumin Zhou 10 , Liren Ding 11 , Ting Yang 12 , Wanzhen Yao 14 , Yanfei Guo 15 , Fei Xiao 18 , Yong Lu 13 , Xiaoxia Peng 19 , Biao Zhang 16 , Dan Xiao 20 , Zuomin Wang 21 , Hong Zhang 13 , Xiaoning Bu 13 , Xiaolei Zhang 1 , Li An 13 , Shu Zhang 13 , Zhixin Cao 13 , Qingyuan Zhan 1 , Yuanhua Yang 13 , Lirong Liang 22 , Bin Cao 1 , Huaping Dai 1 , Aaron van Donkelaar 23 , Randall V Martin 23 , Tangchun Wu 24 , Jiang He 25 , Haidong Kan 2 , Chen Wang 26 ,
Affiliation  

The associations of long-term exposure to various constituents of fine particulate matter (≤2.5 μm in aerodynamic diameter, PM2.5) air pollution with lung function were not clearly elucidated in developing countries. The aim was to evaluate the associations of long-term exposure to main constituents of PM2.5 with lung function in China. This is a nationwide, cross-sectional analysis among 50,991 study participants from the China Pulmonary Health study. Multivariable linear regression models were used to obtain differences of forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC), FEV1/FVC, peak expiratory flow (PEF), and forced expiratory flow at 25–75% of exhaled FVC (FEF25-75%) associated with an interquartile range (IQR) change of PM2.5 or its constituents. Residential annual PM2.5 levels varied from 26 μg/m3 to 92 μg/m3 (average: 53 μg/m3). An IQR increase of PM2.5 concentrations was associated with lower FEV1 (19.82 mL, 95% CI: 11.30–28.33), FVC (17.45 mL, 95% CI: 7.16–27.74), PEF (86.64 mL/s, 95% CI: 59.77–113.52), and FEF25-75% (31.93 mL/s, 95% CI: 16.64–47.22). Black carbon, organic matter, ammonium, sulfate, and nitrate were negatively associated with most lung function indicators, with organic matter and nitrate showing consistently larger magnitude of associations than PM2.5 mass. This large-scale study provides first-hand epidemiological evidence that long-term exposure to ambient PM2.5 and some constituents, especially organic matter and nitrate, were associated with lower large- and small- airway function.

更新日期:2021-06-28
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