Background Observational epidemiological studies propose that variations in thyroid function are associated with the risk of dementia; however, there have been inconsistent findings regarding the direction of the association. It is still unclear whether these associations are causal or not. We aim to test whether genetically determined variation within the normal range of thyroid function and hypothyroidism are causally associated with the risk of Alzheimer’s disease (AD).

中文翻译：

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甲状腺功能和阿尔茨海默病的风险：孟德尔随机化研究

背景观察性流行病学研究表明，甲状腺功能的变化与痴呆风险有关；然而，关于该协会的方向的调查结果不一致。目前尚不清楚这些关联是否具有因果关系。我们旨在测试甲状腺功能和甲状腺功能减退症正常范围内的遗传变异是否与阿尔茨海默病 (AD) 的风险存在因果关系。