Abstract Ten 5-bromoindole-2-carboxamides were synthesized, characterized and evaluated for antibacterial activity against pathogenic Gram-negative bacteria Klebsiella pneumoniae, Escherichia coli, Pseudomonas aeruginosa and Salmonella Typhi using gentamicin and ciprofloxacin as internal standards. Compounds 7a–c, 7g and 7h exhibit high antibacterial activity with a minimum inhibitory concentration (MIC) of 0.35–1.25 μg/mL. Compounds 7a–c exhibit antibacterial activities that are higher than those of the standards against E. coli and P. aeruginosa.

中文翻译：

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5-Bromo-1-(4-chlorobenzyl)-1H-indole-2-carboxamides 作为新型强效抗菌剂

摘要 以庆大霉素和环丙沙星为内标，合成、表征和评价了10种5-溴吲哚-2-甲酰胺对致病性革兰氏阴性菌肺炎克雷伯菌、大肠杆菌、铜绿假单胞菌和伤寒沙门氏菌的抗菌活性。化合物 7a-c、7g 和 7h 表现出高抗菌活性，最低抑菌浓度 (MIC) 为 0.35-1.25 μg/mL。化合物 7a-c 的抗菌活性高于标准品对大肠杆菌和铜绿假单胞菌的抗菌活性。