Abstract A series of novel perfluoropropan-2-yl-based quinoline derivatives was designed and synthesized utilizing tebufloquin as the lead compound. The structures of all the newly synthesized compounds were confirmed by spectroscopic data 1HNMR, MS and elemental analysis. The results of bioassay indicated that these compounds exhibited potent fungicidal activities against Erysiphe graminis. Especially, compound 8c displayed excellent activity with EC50 value at 1.48 mg / L, which was better than that of the commercialized fungicide --- tebufloquin. The structure-activity relationship for these new compounds was also discussed.

中文翻译：

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基于全氟丙-2-基的新型喹啉衍生物的合成及杀菌活性

摘要 以戊氟喹为先导化合物，设计合成了一系列新型全氟丙-2-基喹啉衍生物。所有新合成化合物的结构均通过光谱数据1HNMR、MS和元素分析证实。生物测定结果表明，这些化合物对禾本科白粉菌表现出强效的杀真菌活性。尤其是化合物8c表现出优异的活性，EC50值为1.48 mg/L，优于商品化杀菌剂——tebufloquin。还讨论了这些新化合物的构效关系。