Abstract An efficient, short and, a convenient asymmetric total synthesis of filamentous fungi related resorcylic acid lactones 7-epi-zeaenol (2) and zeaenol (1) have been achieved in 7 and 9 linear steps with the high overall yield of 32% and 21% respectively, from the known intermediate 13. Mitsunobu inversion, De Brabander’s protocol for macrolactonisation, Heck cross-coupling, diastereoselective alkyne aldehyde coupling and Ohira–Bestmann alkynylation are the key reactions.

中文翻译：

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丝状真菌相关间苯二酸内酯 7-epi-zeaenol 和 zeaenol 的不对称全合成

摘要 丝状真菌相关间苯二酸内酯 7-epi-zeaenol (2) 和 zeaenol (1) 的高效、短程和方便的不对称全合成已通过 7 和 9 个线性步骤实现，总收率高达 32% 和分别为 21%，来自已知的中间体 13。Mitsunobu 反转、De Brabander 的大环内酯化方案、Heck 交叉偶联、非对映选择性炔醛偶联和 Ohira-Bestmann 炔基化是关键反应。