Abstract An improved synthesis of 2-ethyl-5-(2-hydroxy-4-oxoquinolin-3(4H)-ylidene)-6-aryl-5,6-dihydroimidazo[2,1-b][1,3,4]thiadiazol-7-ium hydroxide derivatives 4a–k via the reaction of aryl glyoxal monohydrates 1a–k, quinoline-2,4-diol 2 and 2-amino-[1,3,4]thiadiazole (3) in the presence of Et3N/sulfamic acid in H2O is described. This green protocol is characterized by the use of the readily available catalyst and reactants, short reaction times, operational simplicity and high yields of products. The structures of all compounds were characterized by 1H NMR, 13C NMR and Fourier-transform infrared (FT-IR) spectral data and microanalyses.

中文翻译：

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通过在水中的一锅三组分反应有效合成咪唑并[2,1-b][1,3,4]噻二唑-7-鎓氢氧化物

摘要 2-乙基-5-(2-羟基-4-oxoquinolin-3(4H)-ylidene)-6-aryl-5,6-dihydroimidazo[2,1-b][1,3,4 ]噻二唑-7-鎓氢氧化物衍生物 4a-k 通过芳基乙二醛一水合物 1a-k、喹啉-2,4-二醇 2 和 2-氨基-[1,3,4] 噻二唑 (3) 在描述了 H2O 中的 Et3N/氨基磺酸。这种绿色协议的特点是使用容易获得的催化剂和反应物、反应时间短、操作简单和产品收率高。所有化合物的结构均通过 1H NMR、13C NMR 和傅里叶变换红外 (FT-IR) 光谱数据和微量分析进行表征。