Abstract Norfloxacin-azole hybrids 3 and 6a,b were synthesized starting from norfloxacin. The treatment of these compounds with amines as a one-pot three-component reaction produced the corresponding amino derivatives 4a,b, 7a–g and 8a,b in good yields. The conventional and microwave-assisted methods were used with the latter method being more efficient. The structures of the synthesized compounds were characterized by elemental analysis, IR, 1H NMR, 13C NMR and MS. All compounds were screened for their antimicrobial activities. Most of them exhibit excellent antibacterial activity but are not active against selected fungi.

中文翻译：

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新型诺氟沙星-唑类杂合体的合成及抗菌活性评价

摘要 以诺氟沙星为原料合成了诺氟沙星-唑类杂化物3和6a、b。用胺处理这些化合物作为一锅三组分反应产生相应的氨基衍生物 4a,b, 7a-g 和 8a,b，产率很高。使用常规方法和微波辅助方法，后一种方法更有效。合成化合物的结构通过元素分析、IR、1H NMR、13C NMR和MS表征。筛选所有化合物的抗微生物活性。它们中的大多数表现出优异的抗菌活性，但对选定的真菌没有活性。