The CNTNAP2 gene has been implicated in several neuropsychological disorders, including autism spectrum disorder (ASD) and schizophrenia. The CNTNAP2 knockout (KO) rat model, rats without the CNTNAP2 gene, exhibits deficits in social interaction and increases in both repetitive and anxiety-like behaviors. However, deficits in time perception that may underlie several of the neuropsychological disorders implicated have not been investigated. The current study investigated timing in CNTNAP2 KO rats compared to control rats using a discrete-trial temporal bisection task. Results suggested deficits in the timing of relatively long durations in the CNTNAP2 KO rats. This finding is consistent with similar findings previously reported in humans diagnosed with ASD, and is promising for understanding the role that the CNTNAP2 gene may play in timing in certain neuropsychological disorders, and for developing targeted clinical therapies.

CNTNAP2 基因与多种神经心理疾病有关，包括自闭症谱系障碍 (ASD) 和精神分裂症。CNTNAP2 敲除 (KO) 大鼠模型，即没有 CNTNAP2 基因的大鼠，在社交互动方面表现出缺陷，并且重复性和类似焦虑的行为均增加。然而，尚未调查可能导致所涉及的几种神经心理障碍的时间感知缺陷。目前的研究使用离散试验时间二分任务调查了 CNTNAP2 KO 大鼠与对照大鼠的时间。结果表明 CNTNAP2 KO 大鼠相对较长持续时间的时间缺陷。这一发现与之前在被诊断患有 ASD 的人类中报道的类似发现一致，