The aim of the study was to investigate the association of adipokines (resistin, leptin and adiponectin) with obesity, insulin resistance (IR) and inflammation in type 2 diabetes mellitus (T2DM). A total of 284 patients with T2DM were included. Concentrations of resistin, leptin, adiponectin, and inflammatory markers [high sensitivity C-reactive protein (hsCRP), tumor necrosis factor α (TNF-α), and interleukin 6 (IL-6)] were measured and homeostatic model assessment for IR (HOMA-IR) index was calculated. Resistin correlated negatively with estimated glomerular filtration rate (eGFR) and positively with hsCRP, TNF-α, IL-6, and white blood cell count (WBC). Leptin correlated positively with HOMA-IR, whereas adiponectin correlated negatively. Leptin also correlated positively with body mass index (BMI), waist circumference, IL-6, WBC and negatively with eGFR. Adiponectin correlated negatively with waist circumference, WBC, and eGFR. Multivariate logistic regression indicated lower eGFR and higher WBC and IL-6 as independent predictive factors of resistin concentration above the upper quartile (CAQ3), whereas female sex and higher BMI and HOMA-IR of leptin CAQ3, and lower HOMA-IR and older age of adiponectin CAQ3. In conclusion, in contrast to leptin and adiponectin, in T2DM patients, resistin is not associated with BMI and IR, but with inflammation and worse kidney function.

中文翻译：

---

抵抗素与炎症和肾功能有关，但与 2 型糖尿病的胰岛素抵抗无关

该研究的目的是调查脂肪因子（抵抗素、瘦素和脂联素）与肥胖、胰岛素抵抗 (IR) 和 2 型糖尿病 (T2DM) 炎症的关系。总共包括 284 名 T2DM 患者。测量抵抗素、瘦素、脂联素和炎症标志物 [高敏 C 反应蛋白 (hsCRP)、肿瘤坏死因子α (TNF-α) 和白细胞介素 6 (IL-6)] 的浓度并评估 IR 的稳态模型。 HOMA-IR) 指数被计算。抵抗素与估计的肾小球滤过率 (eGFR) 呈负相关，与 hsCRP、TNF-α、IL-6 和白细胞计数 (WBC) 呈正相关。瘦素与 HOMA-IR 呈正相关，而脂联素呈负相关。瘦素还与体重指数 (BMI)、腰围、IL-6、WBC 和 eGFR 阴性。脂联素与腰围、WBC 和 eGFR 呈负相关。多变量逻辑回归表明较低的 eGFR 和较高的 WBC 和 IL-6 作为抵抗素浓度高于上四分位数 (CAQ3) 的独立预测因素，而女性和瘦素 CAQ3 的 BMI 和 HOMA-IR 较高，以及较低的 HOMA-IR 和年龄较大脂联素 CAQ3。总之，与瘦素和脂联素相比，在 T2DM 患者中，抵抗素与 BMI 和 IR 无关，但与炎症和肾功能恶化有关。而女性和瘦素 CAQ3 的 BMI 和 HOMA-IR 较高，而脂联素 CAQ3 的 HOMA-IR 较低和年龄较大。总之，与瘦素和脂联素相比，在 T2DM 患者中，抵抗素与 BMI 和 IR 无关，但与炎症和肾功能恶化有关。而女性和瘦素 CAQ3 的 BMI 和 HOMA-IR 较高，而脂联素 CAQ3 的 HOMA-IR 较低和年龄较大。总之，与瘦素和脂联素相比，在 T2DM 患者中，抵抗素与 BMI 和 IR 无关，但与炎症和肾功能恶化有关。