An asymmetric [4+3] cyclization reaction of racemic 4-indolylmethanols and quinone esters catalyzed by chiral phosphoric acids has been developed. This method provides efficient access to biologically important benzoxepino[5,4,3-cd] indoles featuring both axial and central chirality in good yields with up to 98% ee and essentially single diastereomer in mild reaction conditions.

中文翻译：

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手性磷酸催化4-吲哚甲醇和醌酯的对映选择性[4+3]环化反应

已经开发了由手性磷酸催化的外消旋 4-吲哚甲醇和醌酯的不对称 [4+3] 环化反应。该方法提供了对生物学上重要的苯并氧杂表 [5,4,3-cd] 吲哚的有效获取，这些吲哚具有轴向和中心手性，产率高达 98%，在温和的反应条件下基本上是单一的非对映异构体。