Abstract

This is the first study to analyze the variability of two exons (the 1st and 3rd) of the VCORC1 gene in Russian populations of mice and rats, namely, 125 Mus musculus and 19 Rattus norvegicus captured in 13 settlements. Previously, it has been shown that a number of mutations in these exons in the countries of Western Europe are associated with resistance to anticoagulants in synanthropic rodents. We did not find such mutations in house mice in Russia. However, in the first exon, two previously unknown mutations were identified that could potentially have such an effect (Lys58Arg and Ser31Trp). In three districts of Moscow, Norway rats were found carrying in the third exon a previously known resistance mutation (Tyr139Ser) in the heterozygous state. The results are discussed in connection with the intensity of the use of anticoagulants in the settlements of Russia and the mutation rate of the VCORC1 gene.

中文翻译：

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俄罗斯城市化地区共生啮齿动物抗凝血剂VCORC1基因突变

摘要

这是第一项分析俄罗斯小鼠和大鼠种群中VCORC1基因的两个外显子（第一个和第三个）变异性的研究，即 125 Mus musculus和 19 Rattus norvegicus在 13 个定居点被俘。以前，已经表明，西欧国家这些外显子的一些突变与同人类啮齿动物对抗凝剂的抗性有关。我们在俄罗斯的家鼠身上没有发现这种突变。然而，在第一个外显子中，发现了两个以前未知的突变，它们可能会产生这种影响（Lys58Arg 和 Ser31Trp）。在莫斯科的三个地区，发现挪威大鼠在第三个外显子中携带先前已知的杂合状态抗性突变（Tyr139Ser）。讨论结果与俄罗斯定居点抗凝剂的使用强度和VCORC1基因的突变率有关。