Objectives: To investigate the changes of functional connectivity between vermis and cerebral regions in resting state in Bipolar disorder (BD). Methods: Thirty participants with BD and 28 healthy controls (HC) underwent resting-state functional magnetic resonance imaging (fMRI). Resting-state functional connectivity (rsFC) of the vermis divided into anterior and posterior vermis was examined. For each participant, rsFC maps of the anterior and posterior vermis were computed and compared across the two groups. Results: Compared to the HC group, we found significant decreases in rsFC between the whole vermis and ventral prefrontal cortex (VPFC) in the BD groups, whereas rsFC between the anterior vermis and the middle cingulate cortex was significantly decreased in the BD group. Limitations: 83.3% of the BD participants were taking medication at the time of the study. We did not examine the effects of medication on rsFC in this study. Hence, our findings may in part be attributed to treatment differences; the mixed BD subtypes in our current study may have confounding effects on the results. Conclusions: These results strongly suggest that these rsFC differences of vermis-VPFC between groups may play a key role in the regulation of mood in BD.

中文翻译：

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双相情感障碍中蚓腹前额叶皮层的功能连接性降低

目的：探讨双相情感障碍（BD）静息状态下蚓部与脑区功能连接的变化。方法：30 名 BD 参与者和 28 名健康对照组 (HC) 接受了静息状态功能磁共振成像 (fMRI)。检查分为前蚓部和后部蚓部的静息状态功能连接（rsFC）。对于每个参与者，计算并比较两组的前后蚓部的 rsFC 图。结果：与 HC 组相比，我们发现 BD 组整个蚓部和腹侧前额叶皮层（VPFC）之间的 rsFC 显着降低，而 BD 组前蚓部和中扣带皮层之间的 rsFC 显着降低。限制：83。3% 的 BD 参与者在研究期间正在服药。在本研究中，我们没有检查药物对 rsFC 的影响。因此，我们的发现可能部分归因于治疗差异；我们目前研究中的混合 BD 亚型可能对结果产生混淆影响。结论：这些结果强烈表明，这些组间 vermis-VPFC 的 rsFC 差异可能在 BD 的情绪调节中起关键作用。