The current project deals with designing and synthesizing of colourimetric chemosensors to detect the cations in the aqueous medium and biological sample. To achieve this goal a new series of quinazolinone derivatives have been synthesized via reaction of the novel 6-nitro-2-propyl-4H-benzo[d][1,3]oxazin-4-one 3 with selected nitrogen nucleophiles, namely, formamide, hydrazine hydrate, hydroxylamine hydrochloride, o-phenylendiamine, o-aminophenol and o-aminothiophenol, urea and/or thiourea. Structures of the new compounds have been investigated depending on their spectral data (IR, ¹H and ¹³C NMR and MS) and elemental analyses. Some of the newly synthesized products exhibit significant response as chemosensors for a few cations detection.

中文翻译：

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含有喹唑啉酮部分的新型比色化学传感器的设计、合成和评估，用于检测水介质和生物样品中的某些阳离子

目前的项目涉及比色化学传感器的设计和合成，以检测水介质和生物样品中的阳离子。为了实现这一目标，通过新型 6-硝基-2-丙基-4 H-苯并[ d ][1,3]恶嗪-4-one 3与选定的氮亲核试剂反应，合成了一系列新的喹唑啉酮衍生物，即酰胺，甲酰胺，水合肼，盐酸羟胺，ö -phenylendiamine，ö氨基苯酚和ø -aminothiophenol，脲和/或硫脲。已根据新化合物的光谱数据（IR、¹ H 和¹³C NMR 和 MS）和元素分析。一些新合成的产品作为化学传感器对少数阳离子检测表现出显着的响应。