Cobalt ferrite (CoFe₂O₄) nanoparticles with three distinct grain sizes of 13, 17, and 21 nm were successfully obtained at relatively low temperature via a facile chemical wet method, namely, hydrothermal method. X-ray diffraction analyses, Fourier transform infrared spectroscopy, and Raman spectroscopy confirmed the pure cubic spinel characteristic of the samples. UV–visible diffuse reflectance spectroscopy was performed to analyze the optical band gap energy of the samples; the direct band gap increased with the increase in grain size. The variation in coercivity with particle size was considered to construct the domain state of the nanoparticles. The magnetic heating efficiency was investigated on the basis of a magnetic fluid with various concentrations of well-dispersed chitosan-coated 13 nm CoFe₂O₄ nanoparticles. In vitro cytotoxicity experiments revealed the non-cytotoxic nature of chitosan-coated CoFe₂O₄ nanoparticles. Moreover, the high value of specific loss power suggested that these nanoparticles may be used as magnetic mediators for magnetic hyperthermia applications.

通过简便的化学湿法，即水热法，在相对较低的温度下成功地获得了具有 13、17 和 21 nm 三种不同粒径的钴铁氧体 (CoFe ₂ O ₄ ) 纳米颗粒。X 射线衍射分析、傅里叶变换红外光谱和拉曼光谱证实了样品的纯立方尖晶石特性。紫外-可见漫反射光谱用于分析样品的光学带隙能量；直接带隙随着晶粒尺寸的增加而增加。的变化矫顽力与粒径被认为是构成纳米颗粒的畴状态。基于具有各种浓度的分散良好的壳聚糖包覆的 13 nm CoFe ₂ O ₄纳米粒子的磁性流体，研究了磁加热效率。体外细胞毒性实验揭示了壳聚糖包覆的 CoFe ₂ O ₄纳米颗粒的非细胞毒性性质。此外，比损耗功率的高值表明这些纳米颗粒可用作磁热疗应用的磁性介质。