Abstract

Nature products have been extensively used in the discovery and development of new drugs, as the most important source of drugs. The triazole ring is one of main pharmacophore of the nitrogen-containing heterocycles. Thus, a new class of triazole-containing natural product conjugates has been synthesised. These compounds reportedly exert anticancer, anti-inflammatory, antimicrobial, antiparasitic, antiviral, antioxidant, anti-Alzheimer, and enzyme inhibitory effects. This review summarises the research progress of triazole-containing natural product derivatives involved in medicinal chemistry in the past six years. This review provides insights and perspectives that will help scientists in the fields of organic synthesis, medicinal chemistry, phytochemistry, and pharmacology.

 抽象的

自然产品作为最重要的药物来源，已广泛应用于新药的发现和开发。三唑环是含氮杂环的主要药效基团之一。因此，合成了一类新的含三唑的天然产物缀合物。据报道，这些化合物具有抗癌、抗炎、抗菌、抗寄生虫、抗病毒、抗氧化、抗阿尔茨海默氏症和酶抑制作用。本文综述了近六年来含三唑类天然产物衍生物在药物化学领域的研究进展。这篇综述提供的见解和观点将有助于有机合成、药物化学、植物化学和药理学领域的科学家。