Determination of the enantiomeric composition of amphetamine, methamphetamine and 3,4-methylendioxy-N-methylamphetamine (MDMA) in seized street drug samples from southern Germany,Drug Testing and Analysis

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Determination of the enantiomeric composition of amphetamine, methamphetamine and 3,4-methylendioxy-N-methylamphetamine (MDMA) in seized street drug samples from southern Germany
Drug Testing and Analysis ( IF 2.6 ) Pub Date : 2021-06-25 , DOI: 10.1002/dta.3118
Moritz Losacker ₁ , Siegfried Zörntlein ₂ , Bernd Schwarze ₃ , Svenja Staudt ₃ , Jörg Röhrich ₁ , Cornelius Hess ₁

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Amphetamine (speed), methamphetamine (crystal meth), and 3,4-methylenedioxy-N-methylamphetamine (MDMA, ecstasy) represent the most frequently abused amphetamine-type stimulants (ATS). Differences in pharmacological potency and metabolism have been shown for the enantiomers of all three stimulants. Legal consequences in cases of drug possession may also differ according to the German law depending on the enantiomeric composition of the seized drug. Therefore, enantioselective monitoring of seized specimens is crucial for legal and forensic casework.

中文翻译：

测定德国南部缉获的街头毒品样品中苯丙胺、甲基苯丙胺和 3,4-亚甲基二氧基-N-甲基苯丙胺 (MDMA) 的对映体组成

苯丙胺（速度）、甲基苯丙胺（冰毒）和 3,4-亚甲二氧基-N-甲基苯丙胺（MDMA，摇头丸）是最常被滥用的苯丙胺类兴奋剂 (ATS)。所有三种兴奋剂的对映异构体都显示出药理效力和代谢的差异。根据德国法律，持有毒品案件的法律后果也可能有所不同，具体取决于缉获毒品的对映体组成。因此，对检获标本的对映选择性监测对于法律和法医案件工作至关重要。

更新日期：2021-06-25

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