Activation of autophagy is part of the innate immune response during viral infections. Autophagy involves the sequestration of endogenous or foreign components from the cytosol within double-membraned vesicles and the delivery of their content to the lysosomes for degradation. As part of innate immune responses, this autophagic elimination of foreign components is selective and requires specialized cargo receptors that function as links between a tagged foreign component and the autophagic machinery. Pathogens have evolved ways to evade their autophagic degradation to promote their replication, and recent research has shown autophagic receptors to be an important and perhaps previously overlooked target of viral autophagy inhibition. This is a brief summary of the recent progress in knowledge of virus-host interaction in the context of autophagy receptors.

中文翻译：

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自噬受体作为病毒靶点

自噬的激活是病毒感染期间先天免疫反应的一部分。自噬涉及从双膜囊泡内的细胞质中隔离内源性或外源性成分，并将其内容物输送到溶酶体进行降解。作为先天免疫反应的一部分，这种外来成分的自噬消除是有选择性的，需要专门的货物受体作为标记外来成分和自噬机制之间的链接。病原体已经进化出逃避自噬降解以促进其复制的方法，最近的研究表明，自噬受体是病毒自噬抑制的重要且可能以前被忽视的目标。