Rheumatoid arthritis (RA) is a systemic inflammatory disease characterized by synovial inflammation leading to progressive joint erosion and, eventually, joint deformities. RA treatment includes anti-inflammatories, corticosteroids, synthetic disease-modifying antirheumatic drugs (DMARDs), and immunosuppressants. Drug administration is associated with adverse reactions, as gastrointestinal ulcers, cardiovascular complications, and opportunistic infections. Wherefore, different plant-derived phytochemical compounds are studied like new therapeutic approach to treatment of RA. Among the phytochemical compounds of plants for treatment of RA, flavonoids, alkaloids and saponins are related for present anti-inflammatory activity and act as physiological and metabolic regulators. They have low toxicity compared to other active plant compounds, so their therapeutic properties are widely studied. The intention of the review is to present an overview of the therapeutics of flavonoids, alkaloids, and saponins for RA. An extensive literature survey was undertaken through different online platforms: PubMed, SciELO, and Virtual Health Library databases, to identify phytochemical compounds used in RA treatment and the descriptors used were medicinal plants, herbal medicines, and rheumatoid arthritis. Seventy-five research and review articles were found to be apt for inclusion into the review. The present study summarizes the phytochemicals isolated from plants that have therapeutic effects on RA models, in vitro and in vivo. The studied substances exerted anti-inflammatory, chondroprotective, immunoregulatory, anti-angiogenic, and antioxidant activities and the most compounds possess good therapeutic properties, valuable for further research for treatment of RA.

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类黄酮、生物碱和皂苷：这些植物来源的化合物是否可以替代治疗类风湿性关节炎？文献综述

类风湿性关节炎 (RA) 是一种全身性炎症性疾病，其特征是滑膜炎症导致进行性关节侵蚀，最终导致关节畸形。RA 治疗包括抗炎药、皮质类固醇、合成的疾病缓解抗风湿药 (DMARD) 和免疫抑制剂。给药与不良反应有关，如胃肠道溃疡、心血管并发症和机会性感染。因此，研究了不同的植物来源的植物化学化合物，就像治疗 RA 的新疗法一样。在用于治疗 RA 的植物植物化学化合物中，黄酮类、生物碱和皂苷与目前的抗炎活性有关，并作为生理和代谢调节剂。与其他活性植物化合物相比，它们的毒性较低，因此它们的治疗特性被广泛研究。该评价的目的是概述类黄酮、生物碱和皂苷对 RA 的治疗。通过不同的在线平台进行了广泛的文献调查：PubMed、SciELO 和虚拟健康图书馆数据库，以确定 RA 治疗中使用的植物化学化合物，使用的描述符是药用植物、草药和类风湿性关节炎。发现 75 篇研究和评论文章适合纳入评论。本研究总结了从植物中分离出的对 RA 模型具有治疗作用的体外和体内植物化学物质。所研究的物质具有抗炎、软骨保护、免疫调节、抗血管生成、