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Reduction in left frontal alpha oscillations by transcranial alternating current stimulation in major depressive disorder is context-dependent in a randomized-clinical trial
medRxiv - Psychiatry and Clinical Psychology Pub Date : 2021-06-23 , DOI: 10.1101/2021.06.17.21258764 Justin Riddle , Morgan L. Alexander , Crystal Edler Schiller , David R. Rubinow , Flavio Frohlich
medRxiv - Psychiatry and Clinical Psychology Pub Date : 2021-06-23 , DOI: 10.1101/2021.06.17.21258764 Justin Riddle , Morgan L. Alexander , Crystal Edler Schiller , David R. Rubinow , Flavio Frohlich
Background Left frontal alpha oscillations are associated with decreased approach motivation and have been proposed as a target for non-invasive brain stimulation for the treatment of depression and anhedonia. Indeed, transcranial alternating current stimulation (tACS) at the alpha frequency reduced left frontal alpha power and was associated with a higher response rate than placebo stimulation in patients with major depressive disorder (MDD) in a recent double-blind placebo controlled clinical trial.
中文翻译:
在一项随机临床试验中,通过经颅交流电刺激减少重度抑郁症患者的左额叶 α 振荡与情境有关
背景左额叶阿尔法振荡与减少的接近动机有关,并已被提议作为非侵入性脑刺激治疗抑郁症和快感缺乏症的目标。事实上,在最近的一项双盲安慰剂对照临床试验中,α 频率的经颅交流电刺激 (tACS) 降低了左额叶 α 功率,并且与重度抑郁症 (MDD) 患者相比安慰剂刺激的反应率更高。
更新日期:2021-06-25
中文翻译:
在一项随机临床试验中,通过经颅交流电刺激减少重度抑郁症患者的左额叶 α 振荡与情境有关
背景左额叶阿尔法振荡与减少的接近动机有关,并已被提议作为非侵入性脑刺激治疗抑郁症和快感缺乏症的目标。事实上,在最近的一项双盲安慰剂对照临床试验中,α 频率的经颅交流电刺激 (tACS) 降低了左额叶 α 功率,并且与重度抑郁症 (MDD) 患者相比安慰剂刺激的反应率更高。