To enhance the efficiency of Fe₃O₄ nanoparticles (NPs), a series of surface modified polyethylene glycol (PEG) coated NPs were prepared by RF plasma. The purpose of this research paper was to synthesize magnetic NPs with cross-linked PEG coating using plasma treatment. We found the optimal values for plasma power (50W) and the polymer concentration are 50W and 5mM respectively. The experimental results showed that after plasma treatment, the aggregation of the NPs decreased and the colloidal stability increased significantly. As a result of the plasma treatment, a rigid surface with fewer pores was generated on the NPs. The temperature stability of the coated NPs in the colloid system was examined inthe presence of an AC magnetic field, which showed an increase after the plasma treatment. To investigate reduction of the burst effect due to coating, an anticancer drug, Tamoxifen, was incorporated into NPs. The results showed that the cross-linking of the NPs coating by plasma reduced the burst effect by 32%.Our results suggest that the surface modification of the PEG coated Fe₃O₄ NPs, using plasma treatment, is a suitable approach for medical applications, such as magnetic hyperthermia, drug delivery, and magnetic resonance imaging.

提高Fe ₃ O ₄的效率纳米颗粒（NPs），一系列表面改性聚乙二醇（PEG）包覆的纳米颗粒是通过射频等离子体制备的。本研究论文的目的是使用等离子体处理合成具有交联 PEG 涂层的磁性纳米颗粒。我们发现等离子体功率 (50W) 和聚合物浓度的最佳值分别为 50W 和 5mM。实验结果表明，经过等离子体处理后，纳米颗粒的聚集减少，胶体稳定性显着增加。作为等离子体处理的结果，在纳米颗粒上产生了具有较少孔的刚性表面。在存在交流磁场的情况下检查了胶体系统中涂层纳米粒子的温度稳定性，在等离子体处理后显示出温度稳定性的增加。为了研究由于涂层引起的爆裂效应的减少，一种抗癌药物，他莫昔芬，被合并到 NPs 中。结果表明，通过等离子体对纳米颗粒涂层的交联使爆裂效应降低了 32%。我们的结果表明，PEG 涂层 Fe 的表面改性使用等离子体处理的₃ O ₄ NPs 是一种适用于医疗应用的方法，例如磁热疗、药物输送和磁共振成像。