Introduction: Increased peripheral inflammation has been consistently documented in both adult and pediatric depression. However, elevated levels of C-reactive protein (CRP), a nonspecific biomarker for inflammation, have been primarily reported in adults; whether CRP plays a similar role in adolescent depression has not been conclusively established. In our prior work, we identified relationships between CRP and reward neurocircuitry in adolescents with psychiatric symptoms (N = 64) but not with depressive symptoms. Extending this work, we sought to examine CRP across the full range of mood and anxiety symptom severity in a larger, clinically diverse cohort of psychotropic medication-free adolescents and healthy controls (HCs).

中文翻译：

---

C-反应蛋白与青少年情绪和焦虑症状之间缺乏关联

简介：在成人和儿童抑郁症中，外周炎症不断增加。然而，C 反应蛋白 (CRP) 水平升高是一种炎症的非特异性生物标志物，主要报道在成人中。CRP 是否在青少年抑郁症中发挥类似作用尚未最终确定。在我们之前的工作中，我们确定了有精神症状（ N  = 64）但没有抑郁症状的青少年的 CRP 和奖赏神经回路之间的关系扩展这项工作，我们试图在一个更大的、临床多样化的无精神药物青少年和健康对照 (HCs) 队列中检查整个情绪和焦虑症状严重程度的 CRP。