Combining single-cell lineage tracing with RNA sequencing has provided unprecedented opportunities to prospectively explore metastatic dynamics in vivo. In this issue of Cancer Cell, Simeonov et al. developed the macsGESTALT lineage recording system to reveal that hybrid EMT states and S100 expression are associated with elevated metastatic abilities in a pancreatic cancer model.

中文翻译：

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谱系追踪揭示转移动力学

将单细胞谱系追踪与 RNA 测序相结合，为前瞻性地探索体内转移动力学提供了前所未有的机会。在本期《癌细胞》中，Simeonov 等人。开发了 macsGESTALT 谱系记录系统，以揭示混合 EMT 状态和S100表达与胰腺癌模型中转移能力的提高有关。