Purpose

Chlamydial genital infections constitute significant sexually transmitted infections worldwide. The often asymptomatic status of C. trachomatis (CT) infections leads to an increased burden on human reproductive health, especially in middle- and low-income settings. Early detection and management of these infections could play a decisive role in controlling this public health burden. The objective of this review is to provide an insight into the evolution of diagnostic methods for CT infections through the development of new molecular technologies, emphasizing on -omics’ technologies and their significance as diagnostic tools both for effective patient management and control of disease transmission.

Methods

Narrative review of the diagnostic methodologies of CT infections and the impact of the introduction of -omics’ technologies on their diagnosis by review of the literature.

Results

Various methodologies are discussed with respect to working principles, required specifications, advantages, and disadvantages. Implementing the most accurate methods in diagnosis is highlighted as the cornerstone in managing CT infections.

Conclusion

Diagnostics based on -omics’ technologies are considered to be the most pertinent modalities in CT testing when compared to other available methods. There is a need to modify these effective and accurate diagnostic tools in order to render them more available and feasible in all settings, especially aiming on turning them to rapid point-of-care tests for effective patient management and disease control.

中文翻译：

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基因组医学时代沙眼衣原体生殖道感染的诊断

 目的

衣原体生殖器感染构成全世界重要的性传播感染。沙眼衣原体(CT) 感染通常无症状，导致人类生殖健康负担增加，特别是在中低收入环境中。早期发现和管理这些感染可以在控制这一公共卫生负担方面发挥决定性作用。本次综述的目的是通过新分子技术的发展，深入了解 CT 感染诊断方法的演变，强调组学技术及其作为有效患者管理和疾病传播控制诊断工具的重要性。

 方法

通过文献回顾，叙述性回顾CT感染的诊断方法以及组学技术的引入对其诊断的影响。

 结果

讨论了各种方法的工作原理、所需规格、优点和缺点。实施最准确的诊断方法被认为是管理 CT 感染的基石。

 结论

与其他可用方法相比，基于组学技术的诊断被认为是 CT 测试中最相关的方式。有必要修改这些有效且准确的诊断工具，以使它们在所有环境中都更加可用和可行，特别是旨在将它们转变为快速的护理点测试，以实现有效的患者管理和疾病控制。