Decreased gamma activity has been reported both in children and adults with attention deficit/hyperactivity disorder (ADHD). However, while ADHD is a lifelong neurodevelopmental disorder, our insight into the associations of spontaneous gamma band activity with age is limited, especially in adults. Therefore, we conducted an explorative study to investigate trajectories of resting gamma activity in adult ADHD patients (N = 42) versus matched healthy controls (N = 59). We investigated the relationship of resting gamma activity (30–48 Hz) with age in four right hemispheric electrode clusters where diminished gamma power in ADHD had previously been demonstrated by our group. We found significant non-linear association between resting gamma power and age in the lower frequency gamma₁ range (30–39 Hz) in ADHD as compared to controls in all investigated locations. Resting gamma₁ increased with age and was significantly lower in ADHD than in control subjects from early adulthood. We found no significant association between gamma activity and age in the gamma₂ range (39–48 Hz). Alterations of gamma band activity might reflect altered cortical network functioning in adult ADHD relative to controls. Our results reveal that abnormal gamma power is present at all ages, highlighting the lifelong nature of ADHD. Nonetheless, longitudinal studies are needed to confirm our results.

据报道，患有注意力缺陷/多动障碍 (ADHD) 的儿童和成人的 γ 活性降低。然而，虽然 ADHD 是一种终生神经发育障碍，但我们对自发伽马带活动与年龄相关性的了解是有限的，尤其是在成年人中。因此，我们进行了一项探索性研究，以调查成人 ADHD 患者（N  = 42）与匹配的健康对照（N  = 59）的静息伽马活动轨迹。我们研究了四个右半球电极簇中静息伽马活动（30-48 Hz）与年龄的关系，我们的小组先前已经证明了 ADHD 中伽马功率降低。我们发现在较低频率伽马中静息伽马功率与年龄之间存在显着的非线性关联与所有调查地点的对照相比，ADHD 的₁范围（30–39 Hz）。静息 gamma ₁随年龄增长而增加，并且在 ADHD 中显着低于成年早期的对照受试者。我们发现 gamma ₂范围（39-48 Hz）中的 gamma 活动与年龄之间没有显着关联。伽马带活动的改变可能反映了成人 ADHD 相对于对照组的皮层网络功能的改变。我们的研究结果表明，异常伽马能量存在于所有年龄段，突出了多动症的终生性质。尽管如此，需要纵向研究来证实我们的结果。