Despite substantial advances in understanding of the molecular features of gliomas, the therapeutic options for these aggressive tumors remain scarce. Rich, Mitchell and colleagues provide their views about a phase 1 clinical trial testing the safety and efficacy of vaccines against cancer expressing mutant metabolic enzyme IDH1 in patients with high-grade glioma.

中文翻译：

---

胶质瘤疫苗

尽管对胶质瘤分子特征的理解取得了实质性进展，但这些侵袭性肿瘤的治疗选择仍然很少。Rich、Mitchell 及其同事就一项 1 期临床试验发表了他们的看法，该试验测试了针对高级别胶质瘤患者的表达突变代谢酶 IDH1 的癌症疫苗的安全性和有效性。