We conducted a pilot clinical study to investigate ex vivo fresh human blood from 93 patients with coronary heart disease (CHD). The results indicated that terahertz (THz) time-domain spectroscopy (TDS) can be used to quantify triglyceride (TG) levels in human blood. Based on the TG concentrations and corresponding THz absorption coefficients, the Pearson correlation analysis demonstrated that the THz absorption coefficients have a significant negative linear correlation with TG concentration. Comparisons between the THz measurements at 0.2 THz and an automatic biochemical analyzer were performed using an additional 20 blood samples, and the results confirmed that the relative error was less than 15%. Our ex vivo human blood study indicates that the THz technique can be used to assess blood TG levels in clinical diagnostic practice.

我们进行了一项试点临床研究，以调查来自 93 名冠心病 (CHD) 患者的离体新鲜人血。结果表明，太赫兹 (THz) 时域光谱 (TDS) 可用于量化人类血液中的甘油三酯 (TG) 水平。基于TG浓度和相应的THz吸收系数，Pearson相关分析表明THz吸收系数与TG浓度呈显着的负线性相关。使用额外的 20 个血样对 0.2 THz 和自动生化分析仪的 THz 测量值进行了比较，结果证实相对误差小于 15%。我们的离体人体血液研究表明，太赫兹技术可用于评估临床诊断实践中的血液 TG 水平。