Background

Maedi-Visna is a complex production-limiting ovine lentiviral disease caused by small ruminant lentivirus (SRLV) infection widespread throughout the world characterised by long immunological and clinical latencies and chronic progressive inflammatory pathology.¹ Previously, an SNP in the ovine TMEM154 gene (Oar_rambouillet_v1.0: chr 17:g.5776842G>A) as well as a short indel variant in the promoter region of ovine CCR5 (Oar_rambouillet_v1.0: chr 19:g.54980459_54980460ins) were reported as markers associated with resistance/susceptibility to SRLV in several sheep breeds globally (OMIA 001694-9940).^2,3 Multiple other genomic regions associated with susceptibility to or control of infection were also reported indicating genetic complexity.⁴ In Switzerland the Valais blacknose sheep (VBS) breed was found to have the highest prevalence of Maedi-Visna among Swiss sheep breeds.⁵

中文翻译：

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瓦莱黑鼻羊小反刍动物慢病毒易感性的遗传评价

背景

Maedi-Visna 是一种复杂的生产限制性绵羊慢病毒病，由小反刍动物慢病毒 (SRLV) 感染引起，其特征是长免疫和临床潜伏期以及慢性进行性炎症病理学特征。¹以前，绵羊TMEM154基因中的一个 SNP (Oar_rambouillet_v1.0: chr 17:g.5776842G>A) 以及绵羊CCR5启动子区域中的一个短插入缺失变体(Oar_rambouillet_v1.0: chr 1950409_409sg)。被报告为与全球几个绵羊品种对 SRLV 的抗性/易感性相关的标记（OMIA 001694-9940）。^{2 , 3}还报告了与感染易感性或控制相关的多个其他基因组区域，表明遗传复杂性。⁴在瑞士，发现瓦莱州黑鼻羊 (VBS) 品种在瑞士绵羊品种中具有最高的 Maedi-Visna 流行率。⁵