Animal Genetics ( IF 1.8 ) Pub Date : 2021-06-24 , DOI: 10.1111/age.13108 Anna Letko 1 , Charis Bützberger 1 , Nathalie Hirter 1 , Julia M Paris 1 , Carlos Abril 2 , Cord Drögemüller 1
Background
Maedi-Visna is a complex production-limiting ovine lentiviral disease caused by small ruminant lentivirus (SRLV) infection widespread throughout the world characterised by long immunological and clinical latencies and chronic progressive inflammatory pathology.1 Previously, an SNP in the ovine TMEM154 gene (Oar_rambouillet_v1.0: chr 17:g.5776842G>A) as well as a short indel variant in the promoter region of ovine CCR5 (Oar_rambouillet_v1.0: chr 19:g.54980459_54980460ins) were reported as markers associated with resistance/susceptibility to SRLV in several sheep breeds globally (OMIA 001694-9940).2,3 Multiple other genomic regions associated with susceptibility to or control of infection were also reported indicating genetic complexity.4 In Switzerland the Valais blacknose sheep (VBS) breed was found to have the highest prevalence of Maedi-Visna among Swiss sheep breeds.5
中文翻译:
瓦莱黑鼻羊小反刍动物慢病毒易感性的遗传评价
背景
Maedi-Visna 是一种复杂的生产限制性绵羊慢病毒病,由小反刍动物慢病毒 (SRLV) 感染引起,其特征是长免疫和临床潜伏期以及慢性进行性炎症病理学特征。1以前,绵羊TMEM154基因中的一个 SNP (Oar_rambouillet_v1.0: chr 17:g.5776842G>A) 以及绵羊CCR5启动子区域中的一个短插入缺失变体(Oar_rambouillet_v1.0: chr 1950409_409sg)。被报告为与全球几个绵羊品种对 SRLV 的抗性/易感性相关的标记(OMIA 001694-9940)。2 , 3还报告了与感染易感性或控制相关的多个其他基因组区域,表明遗传复杂性。4在瑞士,发现瓦莱州黑鼻羊 (VBS) 品种在瑞士绵羊品种中具有最高的 Maedi-Visna 流行率。5