Nanozymes Inspired by Natural Enzymes,Accounts of Materials Research

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Nanozymes Inspired by Natural Enzymes
Accounts of Materials Research ( IF 14.0 ) Pub Date : 2021-06-24 , DOI: 10.1021/accountsmr.1c00074
Ruofei Zhang _{1,

2} , Xiyun Yan _{1,

2,

3} , Kelong Fan _{1,

2,

3}

Affiliation

Nanozymes, nanomaterials with enzyme-like activities with high structural stability, adjustable catalytic activity, functional diversity, recyclability, and feasibility in large-scale preparation, have become a hot spot in the field of artificial enzymes in recent years and are expected to become potential surrogates and competitors for natural enzymes in practical applications. With the development of in-depth research and a wide range of application requirements, creating nanozymes with catalytic performance comparable to or even surpassing that of natural enzymes has been the key research topic in this field. Most of the nanozymes reported in the past were obtained based on random synthesis and screening, for which the catalytic efficiency is far inferior to that of natural enzymes. Natural enzymes that have evolved over hundreds of millions of years have developed a lot of high-efficiency catalysis know-how hidden in their structural features. To create highly active nanozymes, we assumed that there is a general structure–activity relationship between nanozymes and natural enzymes and proposed the nanozyme optimization strategy by grafting the catalytic principles of natural enzymes into the rational design of nanozymes. On the basis of this bioinspired strategy, a series of nanozymes that exhibit similar catalytic activities that are closer to or even beyond those of natural enzymes have been successfully synthesized. By now, rationally designed high-activity bioinspired nanozymes have become a hot topic in the current research on nanozymes.

中文翻译：

受天然酶启发的纳米酶

纳米酶是一种具有类酶活性、结构稳定性高、催化活性可调、功能多样性、可回收性和大规模制备可行性的纳米材料，已成为近年来人工酶领域的热点，并有望成为潜力天然酶在实际应用中的替代品和竞争者。随着研究的深入发展和应用需求的广泛化，创造催化性能与天然酶相当甚至超过天然酶的纳米酶已成为该领域的重点研究课题。以往报道的纳米酶大多是基于随机合成和筛选获得的，其催化效率远不如天然酶。天然酶已经进化了数亿年，在其结构特征中隐藏着许多高效催化技术。为了创造高活性的纳米酶，我们假设纳米酶和天然酶之间存在一般的结构-活性关系，并通过将天然酶的催化原理嫁接到纳米酶的合理设计中来提出纳米酶优化策略。在这种仿生策略的基础上，成功合成了一系列具有相似催化活性的纳米酶，其催化活性更接近甚至超越天然酶。目前，合理设计的高活性仿生纳米酶已成为当前纳米酶研究的热点。

更新日期：2021-07-23

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