The scope of this work was to reduce/eliminate Class 2 and Class 3 solvents, contained in two active pharmaceutical ingredients (APIs), Beclometasone dipropionate (Beclo) and Budesonide (Bude), using supercritical CO₂. The process was carried out at pressures from 80 to 370 bar, CO₂ flow rates between 0.1 and 1.0 kg/h, and at a temperature of 40 °C. When CO₂ density was too low (e.g., at 80 bar and 40 °C), an incomplete extraction of the solvents was obtained. When the extraction pressure was too large (e.g., 370 bar), also a non-negligible co-extraction of solid material was observed. Particles bed caking emerged at CO₂ flow rates larger than 0.7 kg/h. The optimal process conditions were found operating at 200 bar and 40 °C, using a 0.7 kg/h CO₂ flow rate: total final solvent residues of 5 ppm and 52 ppm for Beclo and Bude, respectively, were reached.

这项工作的范围是使用超临界 CO ₂减少/消除包含在两种活性药物成分 (API)，二丙酸倍氯米松 (Beclo) 和布地奈德 (Bude) 中的第 2 类和第 3 类溶剂。该过程在 80 至 370 巴的压力、0.1 至 1.0 kg/h 的CO ₂流速和 40 °C 的温度下进行。当 CO ₂密度过低（例如，在 80 bar 和 40 °C 下）时，溶剂的萃取不完全。当萃取压力太大（例如，370 巴）时，也观察到不可忽略的固体材料共萃取。CO _{2 下}出现颗粒床结块流速大于 0.7 kg/h。发现最佳工艺条件在 200 bar 和 40 °C 下运行，使用 0.7 kg/h CO ₂流速：Beclo 和 Bude 的最终溶剂残留总量分别达到 5 ppm 和 52 ppm。