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Nickel-Catalyzed Regiodivergent Reductive Hydroarylation of Styrenes
Synlett ( IF 2 ) Pub Date : 2021-06-05 , DOI: 10.1055/a-1523-3228 Yuli He , Shaolin Zhu , Yuhang Xue , Jian Chen , Peihong Song
Synlett ( IF 2 ) Pub Date : 2021-06-05 , DOI: 10.1055/a-1523-3228 Yuli He , Shaolin Zhu , Yuhang Xue , Jian Chen , Peihong Song
We report a ligand-controlled nickel-catalyzed reductive hydroarylation of styrenes with predictable and controllable regioselectivity. With a diamine ligand, the reaction produces selective linear hydroarylation products. Alternatively, with a chiral PyrOx ligand, branch-selective enantioenriched 1,1-diarylalkane products are obtained. Preliminary mechanistic results are consistent with a reductive Heck process.
中文翻译:
苯乙烯的镍催化区域发散还原加氢芳基化
我们报告了一种配体控制的镍催化苯乙烯还原加氢芳基化,具有可预测和可控的区域选择性。使用二胺配体,该反应产生选择性线性氢化芳基化产物。或者,使用手性 PyrOx 配体,获得分支选择性对映体富集的 1,1-二芳基烷烃产物。初步机械结果与还原 Heck 过程一致。
更新日期:2021-06-24
中文翻译:
苯乙烯的镍催化区域发散还原加氢芳基化
我们报告了一种配体控制的镍催化苯乙烯还原加氢芳基化,具有可预测和可控的区域选择性。使用二胺配体,该反应产生选择性线性氢化芳基化产物。或者,使用手性 PyrOx 配体,获得分支选择性对映体富集的 1,1-二芳基烷烃产物。初步机械结果与还原 Heck 过程一致。