Process intensification is a well-known and established method to improve ecological and economic efficiency of large-scale chemical processes. Process intensification in form of integrating an in-situ product or intermediate removal can also improve processes. In this study the effects of integrating an intermediate separation in form of an extraction centrifuge and a product separation in form of a pre-purification into a multi-enzyme cascade as well as the potential for further process integration in form of a reactive extraction centrifuge are analyzed for a biotechnological process. In order to evaluate the application of process integration, different process configurations are compared regarding to the efficiency using a model-based approach. Although the highly integrated process leads to lower space-time yields in some cases, an operating window can be identified in which the space-time yield is significantly higher compared to a sequential process. In order to distinguish both cases and thus choose a suitable operating point simulative studies are required. Moreover, a potential for further integration can be identified for the reference process studied in this work.

过程集约化是提高大规模化学过程的生态和经济效率的众所周知的成熟方法。以集成原位的形式进行工艺强化产品或中间体去除也可以改进工艺。在这项研究中，将提取离心机形式的中间分离和预纯化形式的产品分离整合到多酶级联中的影响以及反应提取离心机形式的进一步工艺整合的潜力。分析生物技术过程。为了评估流程集成的应用，使用基于模型的方法比较不同流程配置的效率。尽管在某些情况下，高度集成的工艺会导致较低的时空产率，但可以确定一个操作窗口，其中与顺序工艺相比，时空产率明显更高。为了区分这两种情况并因此选择合适的工作点，需要进行模拟研究。此外，可以确定本工作中研究的参考过程有进一步整合的潜力。