KEY MESSAGES

• Lanadelumab was effective compared with placebo in preventing HAE attacks across various patient subgroups.
• For all subgroups, lanadelumab 300 mg q2w reduced attack rates by >50% during the full treatment period.
• Attack reduction was >50% for most subgroups early on, with further reductions during steady state.

中文翻译：

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lanadelumab 预防遗传性血管性水肿发作的有效性：来自 HELP 研究的亚组分析

关键信息

• 与安慰剂相比，Lanadelumab 在预防不同患者亚组的 HAE 发作方面是有效的。
• 对于所有亚组，lanadelumab 300 mg q2w 在整个治疗期间将发作率降低了 >50%。
• 早期大多数亚组的攻击减少> 50％，在稳定状态下进一步减少。