Background: Stroke is one of the leading causes of adult disability, and up to 80% of stroke survivors undergo upper extremity motor dysfunction. Constraint-Induced Movement Therapy (CIMT) and Robot-Assisted Therapy (RT) are used for upper limb stroke rehabilitation. Although CIMT and RT are different techniques, both are beneficial; however, their results must be compared. The objective is to establish the difference between RT and CIMT after a rehabilitation program for chronic stroke patients. Method: This is a randomized clinical trial, registered at ClinicalTrials.gov (ID number NCT02700061), in which patients with stroke received sessions of RT or CIMT protocol, combined with a conventional rehabilitation program for 12 weeks. The primary outcome was measured by Wolf Motor Function Test (WMFT) and Fugl-Meyer Assessment – Upper Limb (FMA-UL). Activities of daily living were also assessed. Results: 51 patients with mild to moderate upper limb impairment were enrolled in this trial, 25 women and 26 men, mean age of 60,02 years old (SD 14,48), with 6 to 36 months after stroke onset. Function significantly improved regardless of the treatment group. However, no statistical difference was found between both groups as p-values of the median change of function measured by WMFT and FMA were 0.293 and 0.187, respectively. Conclusion: This study showed that Robotic Therapy (RT) was not different from Constraint-Induced Movement Therapy (CIMT) regardless of the analyzed variables. There was an overall upper limb function, motor recovery, functionality, and activities of daily living improvement regardless of the interventions. At last, the combination of both techniques should be considered in future studies.

中文翻译：

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用于中风运动恢复的机器人辅助疗法和约束诱导运动疗法：随机临床试验的结果

背景：中风是导致成人残疾的主要原因之一，高达 80% 的中风幸存者会出现上肢运动功能障碍。约束诱导运动疗法 (CIMT) 和机器人辅助疗法 (RT) 用于上肢中风康复。尽管 CIMT 和 RT 是不同的技术，但两者都是有益的；然而，他们的结果必须进行比较。目的是在慢性中风患者的康复计划后确定 RT 和 CIMT 之间的区别。方法：这是一项在 ClinicalTrials.gov 注册的随机临床试验（ID 号 NCT02700061），其中中风患者接受了 RT 或 CIMT 方案，并结合了 12 周的常规康复计划。主要结果由 Wolf 运动功能测试 (WMFT) 和 Fugl-Meyer 评估 - 上肢 (FMA-UL) 测量。日常生活活动也进行了评估。结果： 51 名轻度至中度上肢功能障碍患者入选该试验，女性 25 名，男性 26 名，平均年龄 60,02 岁 (SD 14,48)，卒中发病后 6 至 36 个月。无论治疗组如何，功能都显着改善。然而，两组之间没有发现统计学差异，因为 WMFT 和 FMA 测量的功能变化中位数的 p 值分别为 0.293 和 0.187。结论：这项研究表明，无论分析的变量如何，机器人疗法 (RT) 与约束诱导运动疗法 (CIMT) 都没有区别。无论采取何种干预措施，总体上肢功能、运动恢复、功能和日常生活活动都得到改善。最后，