Diabetes mellitus (DM) is associated with a specific cardiac phenotype characterized by structural and functional alterations. This so-called diabetic cardiomyopathy (DM CM) is clinically relevant as patients with DM show high incidence of heart failure. Mechanistically, several parameters interact on the cardiomyocyte level leading to increased inflammation, apoptosis, reactive oxygen species and altered calcium signaling. This in turn provokes functional myocardial changes that might inter alia play into the worsened clinical outcome in DM patients. Therefore, efficient therapeutic options are urgently needed. This review focuses on mechanistic effects of currently recommended antidiabetic treatment and heart failure therapy for DM CM.

糖尿病 (DM) 与以结构和功能改变为特征的特定心脏表型相关。这种所谓的糖尿病性心肌病 (DM CM) 具有临床意义，因为 DM 患者的心力衰竭发生率很高。从机制上讲，几个参数在心肌细胞水平上相互作用，导致炎症、细胞凋亡、活性氧种类增加和钙信号改变。这反过来会引起功能性心肌变化，这些变化尤其可能导致 DM 患者的临床结果恶化。因此，迫切需要有效的治疗选择。本综述侧重于目前推荐的 DM CM 抗糖尿病治疗和心力衰竭治疗的机制效应。