Cortical thickness (CT) and local gyrification index (LGI) in psychotic disorders may show modifications that relate to clinical course. This observational study aimed to analyse such variables in patients with schizophrenia, compared to healthy controls (HCs). We compared CT and LGI of 18 patients with first-episode psychosis with that of 21 with multi-episode schizophrenia and 16 HCs. CT corrected for false-positive cases (Family-Wise Error Rate) showed a reduction in the multi-episode group compared to HCs in left temporal and parietal, and right temporal, parietal, occipital, and hippocampal cortices. Family-wise corrected LGI was increased in the left inferior and middle frontal cortices, and in the right fusiform gyrus, cingulate, lingual, and parahippocampal gyri in first onset patients compared to HCs. Increased LGI was absent from later stages of psychosis, suggesting that specific CT and LGI alterations may underlie different stages of illness.

中文翻译：

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首发精神病和多发精神分裂症的大脑皮层厚度和回旋变化。

精神病患者的皮质厚度 (CT) 和局部旋转指数 (LGI) 可能显示与临床病程相关的变化。这项观察性研究旨在分析精神分裂症患者与健康对照 (HC) 相比的此类变量。我们将 18 名首发精神病患者的 CT 和 LGI 与 21 名多发作精神分裂症和 16 名 HC 患者的 CT 和 LGI 进行了比较。CT 校正假阳性病例（家庭错误率）显示，与左侧颞叶和顶叶以及右侧颞叶、顶叶、枕叶和海马皮质中的 HC 相比，多集组的减少。与 HC 相比，首发患者的左下和中额叶皮质以及右侧梭状回、扣带回、舌回和海马旁回的家庭校正 LGI 增加。