Manipulating different signaling pathways via small molecules could efficiently induce cardiomyocytes from human induced pluripotent stem cells (hiPSC). However, the effect of transcription factors on the hiPSC-directed cardiomyocytes differentiation remains unclear. Transcription factor, p53 has been demonstrated indispensable for the early embryonic development and mesendodermal differentiation of embryonic stem cells (ESC). We tested the hypothesis that p53 promotes cardiomyocytes differentiation from human hiPSC.

中文翻译：

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p53 通过 Wnt 信号介导的中内胚层分化促进心肌细胞从 hiPSC 分化。

通过小分子操纵不同的信号通路可以有效地诱导人诱导多能干细胞 (hiPSC) 的心肌细胞。然而，转录因子对hiPSC定向心肌细胞分化的影响仍不清楚。转录因子 p53 已被证明对于胚胎干细胞 (ESC) 的早期胚胎发育和中内胚层分化必不可少。我们检验了 p53 促进心肌细胞从人 hiPSC 分化的假设。