The increased expression for the Fms-related tyrosine kinase-4 (FLT-4, known as VEGFR-3) is relevant to dysfunctional natural killer (NK) cells in acute myeloid leukemia (AML). MAZ51 (M), a VEGFR-3 inhibiting chemical, was effectively restored the function of NK cells via the high expression of interferon- gamma (IFN-γ) in NK cells, as shown in our previous study. Although tremendous amount of clinical data using peptides are currently available in real clinic, peptides targeting FLT-4 in modulating immune cells such as NK cells are not fully elucidated.

中文翻译：

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靶向 Fms 相关酪氨酸激酶 4 的肽激活自然杀伤细胞在急性髓性白血病中的功能。

Fms 相关酪氨酸激酶 4（FLT-4，称为 VEGFR-3）的表达增加与急性髓性白血病 (AML) 中功能失调的自然杀伤 (NK) 细胞有关。如我们之前的研究所示， MAZ51 (M) 是一种 VEGFR-3 抑制化学物质，通过 NK 细胞中干扰素-γ (IFN- γ )的高表达有效地恢复了 NK 细胞的功能。尽管目前在实际临床中可以获得大量使用肽的临床数据，但针对 FLT-4 调节免疫细胞（如 NK 细胞）的肽尚未完全阐明。