ABSTRACT

MiRNAs represent a mechanism that regulates gene expression in many pathological conditions. Exosomes are known to be secreted from all types of cells, and the exosomes-released molecules are crucial messengers that can regulate cellular processes. We investigated the miRNAs content of exosomes released by cancer cells during the invasion . An invasion stimulus has been generated through scratches created on the confluent cells of cancer cell lines: glioblastoma, breast and prostate cancers.

Several miRNAs were found to be significantly differentially abundant during the cell invasion , both in common among different cell lines and exclusive. Understanding the language codes among cells involved in invasion can lead to the development of therapies that can inhibit cellular communication, slowing or eventually stopping their activity.

摘要

miRNA 代表了在许多病理条件下调节基因表达的机制。已知外泌体由所有类型的细胞分泌，外泌体释放的分子是调节细胞过程的重要信使。我们研究了癌细胞在侵袭过程中释放的外泌体的 miRNA 含量。通过在胶质母细胞瘤、乳腺癌和前列腺癌等癌细胞系的汇合细胞上产生划痕，产生了侵袭刺激。

一些 miRNA 在细胞侵袭过程中被发现丰度存在显着差异，既有不同细胞系共有的，也有排他性的。了解参与入侵的细胞之间的语言代码可以导致开发出抑制细胞通讯、减缓或最终停止其活动的疗法。