Magnetic Resonance Imaging combined with hyperpolarized ¹³C-labelled metabolic contrast agents produced via dissolution Dynamic Nuclear Polarization can, non-invasively and in real-time, report on tissue specific aberrant metabolism. However, hyperpolarization equipment is expensive, technically demanding and needs to be installed on-site for the end-user. In this work, we provide a robust methodology that allows remote production of the hyperpolarized ¹³C-labelled metabolic contrast agents. The methodology, built on photo-induced thermally labile radicals, allows solid sample extraction from the hyperpolarization equipment and several hours’ lifetime of the ¹³C-labelled metabolic contrast agents at appropriate storage/transport conditions. Exemplified with [U-¹³C, d₇]-D-glucose, we remotely produce hyperpolarized ¹³C-labelled metabolic contrast agents and generate above 10,000-fold liquid-state Magnetic Resonance signal enhancement at 9.4 T, keeping on-site only a simple dissolution device.

磁共振成像与通过溶解动态核极化产生的超极化¹³ C 标记代谢造影剂相结合，可以非侵入性地实时报告组织特异性异常代谢。然而，超极化设备价格昂贵，技术要求高，并且需要为最终用户现场安装。在这项工作中，我们提供了一种强大的方法，可以远程生产超极化¹³ C 标记的代谢造影剂。该方法基于光诱导的热不稳定自由基，允许从超极化设备中提取固体样品，并在适当的储存/运输条件下使¹³ C 标记的代谢造影剂具有数小时的使用寿命。以 [U- ¹³ C, d ₇ ]-D-葡萄糖为例，我们远程生产超极化¹³ C 标记代谢造影剂，并在 9.4 T 下产生超过 10,000 倍的液态磁共振信号增强，仅在现场保持简单的溶解装置。