We test the validity of a possible schematization of DNA structure and dynamics based on the Chern-Simons theory, that is a topological field theory mostly considered in the context of effective gravity theories. By means of the expectation value of the Wilson Loop, derived from this analogue gravity approach, we find the point-like curvature of genomic strings in KRAS human gene and COVID-19 sequences, correlating this curvature with the genetic mutations. The point-like curvature profile, obtained by means of the Chern-Simons currents, can be used to infer the position of the given mutations within the genetic string. Generally, mutations take place in the highest Chern-Simons current gradient locations and subsequent mutated sequences appear to have a smoother curvature than the initial ones, in agreement with a free energy minimization argument.

中文翻译：

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通过陈-西蒙斯电流进行 DNA 突变

我们测试了基于陈-西蒙斯理论的 DNA 结构和动力学可能模式化的有效性，这是一种主要在有效引力理论背景下考虑的拓扑场理论。通过源自这种模拟重力方法的威尔逊环的期望值，我们找到了 KRAS 人类基因和 COVID-19 序列中基因组串的点状曲率，并将该曲率与基因突变相关联。通过陈-西蒙斯电流获得的点状曲率轮廓可用于推断给定突变在基因串中的位置。通常，突变发生在最高的陈-西蒙斯当前梯度位置，随后的突变序列似乎比初始序列具有更平滑的曲率，