Photolabeling Strategies to Study Membranotropic Peptides Interacting with Lipids and Proteins in Membranes,Bioconjugate Chemistry

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Photolabeling Strategies to Study Membranotropic Peptides Interacting with Lipids and Proteins in Membranes
Bioconjugate Chemistry ( IF 4.0 ) Pub Date : 2021-06-23 , DOI: 10.1021/acs.bioconjchem.1c00291
Astrid Walrant ₁ , Emmanuelle Sachon _{1,

2}

Affiliation

Membranotropic peptides is a class of peptides that exert their biological action at the level of cell membranes. Understanding how they interact with their different membrane binding partners (lipids, proteins, and/or glycoconjugates) is important to decipher their mechanism of action. Affinity photolabeling is a powerful method to study noncovalent interactions and provide a submolecular picture of the contacts between two interacting partners. In this review, we give a panorama of photolabeling-based studies of the interactions between membranotropic peptides and membranes using either photoreactive lipids or peptides.

中文翻译：

研究与膜中脂质和蛋白质相互作用的亲膜肽的光标记策略

亲膜肽是一类在细胞膜水平上发挥其生物学作用的肽。了解它们如何与其不同的膜结合伙伴（脂质、蛋白质和/或糖缀合物）相互作用对于破译它们的作用机制很重要。亲和光标记是研究非共价相互作用并提供两个相互作用伙伴之间接触的亚分子图片的有效方法。在这篇综述中，我们使用光反应性脂质或肽对亲膜肽和膜之间的相互作用进行了基于光标记的研究。

更新日期：2021-08-19

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