Currently, the rapid global spread of SARS-CoV-2 is related to G clade (including GH, GR, GRY and GV clades), which are associated with more than 98 % of sequenced viral isolates worldwide. The unprecedented velocity of spread of SARS-CoV-2 outbreak represents a critical need for prevention strategies. Vaccines are recently being available and antiviral drugs have shown limited efficacy in COVID-19 patients. Thus, it is needed to know how to reduce the infectivity of the virus by different physicochemical conditions in order to prevent exposure to contaminated material.

This work describes heating and irradiating UV-C light procedures to reduce the infectivity of SARS-CoV-2 belonging to different three lineages. Results of physicochemical treatment showed no differences among viral lineages. Analytical conditions for efficient inactivation of SARS-CoV-2 were determined.

目前，SARS-CoV-2 在全球的快速传播与 G 进化枝（包括 GH、GR、GRY 和 GV 进化枝）有关，这些进化枝与全球 98% 以上的已测序病毒分离株相关。SARS-CoV-2 爆发的前所未有的传播速度代表了对预防策略的迫切需求。疫苗最近面市，抗病毒药物对 COVID-19 患者的疗效有限。因此，需要知道如何通过不同的物理化学条件降低病毒的传染性，以防止接触受污染的材料。

这项工作描述了加热和照射 UV-C 光的程序，以降低属于不同三个谱系的 SARS-CoV-2 的传染性。物理化学处理的结果显示病毒谱系之间没有差异。确定了有效灭活 SARS-CoV-2 的分析条件。