Abstract

We investigate the impact of IL-1A, IL-1B and IL-1R1 polymorphism on lymphoma. This study consisted of 155 Non-Hodgkin’s lymphoma (NHL) patients 55 Hodgkin’s lymphoma (HL) patients and 150 healthy individuals. PCR-RFLP method and ARMS PCR were used for genotyping of IL-1A rs3783553, IL-1B rs3917356, rs16944, IL-1R1 rs10490571 and IL-1A rs3783550 polymorphism. The results showed that the CC genotype of rs3783550 as well Ins/del of rs3783553 increased the risk of NHL. In contrast the AG genotype of rs3917356 and AG also AG + AA genotype of rs10490571 decreased the risk of NHL. The result revealed that the CC genotype of rs3783550 and AG genotype of rs3917356 increased risk of HL.

摘要

我们研究了 IL-1A、IL-1B 和 IL-1R1 多态性对淋巴瘤的影响。该研究包括 155 名非霍奇金淋巴瘤 (NHL) 患者、55 名霍奇金淋巴瘤 (HL) 患者和 150 名健康个体。PCR-RFLP方法和ARMS PCR用于IL-1A rs3783553、IL-1B rs3917356、rs16944、IL-1R1 rs10490571和IL-1A rs3783550多态性的基因分型。结果表明，rs3783550的CC基因型以及rs3783553的Ins/del增加了NHL的风险。相比之下，rs3917356 的 AG 基因型和 rs10490571 的 AG + AA 基因型也降低了 NHL 的风险。结果显示，rs3783550的CC基因型和rs3917356的AG基因型增加了HL的风险。