G protein-coupled receptors (GPCRs) are a large family of cell surface receptors that are the targets for many different classes of pharmacotherapy. The islets of Langerhans are central to appropriate glucose homeostasis through their secretion of insulin, and islet function can be modified by ligands acting at the large number of GPCRs that islets express. The human islet GPCRome is not a static entity, but one that is altered under pathophysiological conditions and, in this review, we have compared expression of GPCR mRNAs in human islets obtained from normal weight range donors, and those with a weight range classified as obese. We have also considered the likely outcomes on islet function that the altered GPCR expression status confers and the possible impact that adipokines, secreted from expanded fat depots, could have at those GPCRs showing altered expression in obesity.

G 蛋白偶联受体 (GPCR) 是一大类细胞表面受体，是许多不同类别药物治疗的靶标。朗格汉斯胰岛通过分泌胰岛素对适当的葡萄糖稳态至关重要，并且胰岛功能可以通过作用于胰岛表达的大量 GPCR 的配体来改变。人类胰岛 GPCRome 不是静态实体，而是在病理生理条件下发生改变的实体，在本综述中，我们比较了从正常体重范围供体和体重范围归类为肥胖的供体获得的人类胰岛中 GPCR mRNA 的表达. 我们还考虑了改变的 GPCR 表达状态可能对胰岛功能产生的影响，以及从扩大的脂肪库分泌的脂肪因子可能产生的影响，