• Nanoparticles hold considerable promise for controlling the local pharmacokinetics of therapeutic agents during osteoarthritis therapy.

• The advantages of nanoparticles, the bioactive design, the transports and interactions within cartilage, and therapeutic mechanisms are discussed.

• This review proposes future strategies to design more intelligent and multi-functional nanomaterials as delivery systems for cartilage therapy.

中文翻译：

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纳米颗粒-软骨相互作用：用于骨关节炎治疗的基于病理学的关节内给药

• 纳米颗粒在骨关节炎治疗期间控制治疗剂的局部药代动力学具有相当大的前景。

• 讨论了纳米粒子的优点、生物活性设计、软骨内的转运和相互作用以及治疗机制。

• 本综述提出了未来设计更多智能和多功能纳米材料作为软骨治疗递送系统的策略。