The current study investigated a novel visual distracter task as a potential diagnostic marker for the detection of cognitive impairment and the extent to which this compares in healthy ageing across two cultures. The Inhibition of a Recent Distracter Effect (IRD) refers to the inhibition of a saccadic eye movement towards a target that is presented at the location of a previous distracter. Two studies compared the IRD across a large cross-cultural sample comprising of young (N = 75), old European participants (N = 119), old south Asian participants (N = 83), participants with Dementia due to Alzheimer's disease (N = 65) and Mild cognitive impairment (N = 91). Significantly longer saccadic reaction times on the target to distracter trials, in comparison to the target to target trials were evident in all groups and age cohorts. Importantly, the IRD was also preserved in participants with Alzheimer's Disease and mild cognitive impairment demonstrating that the IRD is robust across cultures, age groups and clinical populations. Eye-tracking is increasingly used as a dual diagnostic and experimental probe for the investigation of cognitive control in Alzheimer's disease. As a promising methodology for the early diagnosis of dementia, it is important to understand the cognitive operations in relation to eye-tracking that are well preserved as well as those that are abnormal. Paradigms should also be validated across ethnicity/culture, clinical groups and age cohorts.

目前的研究调查了一项新的视觉干扰任务，作为检测认知障碍的潜在诊断标志物，以及这在两种文化中健康老龄化的比较程度。近期干扰物效应 (IRD) 的抑制是指对出现在先前干扰物位置处的目标的扫视眼球运动的抑制。两项研究在一个大型跨文化样本中比较了 IRD，该样本包括年轻的（N = 75）、老年的欧洲参与者（N = 119）、年长的南亚参与者（N = 83）、因阿尔茨海默病导致的痴呆症的参与者（N = 65) 和轻度认知障碍 (N = 91)。与目标到目标试验相比，目标到分散试验的扫视反应时间明显更长，在所有组和年龄组中都很明显。重要的，IRD 在患有阿尔茨海默病和轻度认知障碍的参与者中也得到了保留，这表明 IRD 在不同文化、年龄组和临床人群中都是稳健的。眼动追踪越来越多地用作研究阿尔茨海默病认知控制的双重诊断和实验探针。作为早期诊断痴呆症的一种有前途的方法，重要的是了解与眼动追踪相关的认知操作，这些操作被很好地保存以及异常。范式还应在种族/文化、临床组和年龄组之间进行验证。眼动追踪越来越多地用作研究阿尔茨海默病认知控制的双重诊断和实验探针。作为早期诊断痴呆症的一种有前途的方法，重要的是了解与眼动追踪相关的认知操作，这些操作被很好地保存以及异常。范式还应在种族/文化、临床组和年龄组之间进行验证。眼动追踪越来越多地用作研究阿尔茨海默病认知控制的双重诊断和实验探针。作为早期诊断痴呆症的一种有前途的方法，重要的是了解与眼动追踪相关的认知操作，这些操作被很好地保存以及异常。范式还应在种族/文化、临床组和年龄组之间进行验证。