Fatty acid binding protein 5 (FABP5) has been reported to play an important role in various cancers. We found that high FABP5 expression was associated with poor histological differentiation and vascular invasion. High FABP5 expression indicated a poor prognosis. Downregulation of FABP5 suppressed cell proliferation, cell migration and invasion, and induced cell apoptosis. Bioinformatic analysis revealed that the Hippo signaling pathway was related to FABP5. We found that overexpression of yes-associated protein 1 (YAP1) could partially reverse the effect of FABP5 knockdown on growth and apoptosis. The FABP5 inhibitor SBFI-26 suppressed the proliferation and promoted the apoptosis of gastric cancer (GC) cells and interfered with the Hippo signaling pathway by inhibiting YAP1. Our data suggested that FABP5 might act as a potential target associated with the Hippo signaling pathway for GC treatment.

中文翻译：

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FABP5下调通过河马信号通路抑制胃癌细胞增殖并诱导其凋亡

据报道，脂肪酸结合蛋白 5 ( FABP5 ) 在各种癌症中发挥重要作用。我们发现高FABP5表达与组织学分化差和血管浸润有关。高FABP5表达表明预后不良。FABP5 的下调抑制细胞增殖、细胞迁移和侵袭，并诱导细胞凋亡。生物信息学分析表明Hippo信号通路与FABP5有关。我们发现 yes 相关蛋白 1 (YAP1) 的过表达可以部分逆转FABP5敲低对生长和细胞凋亡的影响。该FABP5抑制剂SBFI-26抑制胃癌（GC）细胞的增殖并促进其凋亡，并通过抑制YAP1干扰Hippo信号通路。我们的数据表明FABP5可能作为与 Hippo 信号通路相关的潜在靶点，用于 GC 治疗。